Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center

Autor: Stacene R. Maroushek, Yiong Huak Chan, Tina M. Slusher, Daniel A. Gbadero, Michael Abel Alao, Adanze Onyenonachi Asinobi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Bacterial Diseases
RNA viruses
Male
Pediatrics
Physiology
Economics
Treatment outcome
Human immunodeficiency virus (HIV)
Antitubercular Agents
Social Sciences
HIV Infections
Economic Geography
medicine.disease_cause
Pathology and Laboratory Medicine
Geographical Locations
Tertiary Care Centers
0302 clinical medicine
Continuous evaluation
Medical Conditions
Immunodeficiency Viruses
Risk Factors
Global health
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Child
Aged
80 and over
Multidisciplinary
Geography
Middle Aged
Socioeconomic Aspects of Health
Body Fluids
Actinobacteria
Infectious Diseases
Treatment Outcome
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
Medicine
Tuberculosis Diagnosis and Management
Low and Middle Income Countries
Female
medicine.symptom
Pathogens
Anatomy
0305 other medical science
Research Article
Adult
medicine.medical_specialty
Tuberculosis
Adolescent
Science
MEDLINE
Nigeria
Microbiology
03 medical and health sciences
Young Adult
Diagnostic Medicine
Retroviruses
medicine
Humans
Microbial Pathogens
Directly Observed Therapy
Aged
Retrospective Studies
030505 public health
Bacteria
business.industry
Lentivirus
Organisms
Sputum
Infant
Newborn
Biology and Life Sciences
HIV
Infant
medicine.disease
Tropical Diseases
Health Care
Treatment Adherence and Compliance
Mucus
People and Places
Africa
Earth Sciences
business
Mycobacterium Tuberculosis
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0239225 (2020)
ISSN: 1932-6203
Popis: IntroductionTuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.MethodsThis study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.ResultsOut of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases. The annual mean measured treatment outcomes were as follows: adherence, 91.4(±5.8) %; successful outcome, 75.3(±8.8) % potentially unsatisfactory outcome, 14.8(±7.2) %; and mortality 10.0(±3.6) %. Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.ConclusionThe mean annual successful treatment outcome is 75.3(±8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications.
Databáze: OpenAIRE
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