Adoptive transfer of immunity to Plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide
| Autor: | Avivah Zuckerman, R.L. Jacobson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adoptive cell transfer
Cyclophosphamide Plasmodium berghei Population Drug Resistance Spleen Biology Immune system Immunity medicine Animals education education.field_of_study Immunization Passive biology.organism_classification Malaria Rats Blood Infectious Diseases medicine.anatomical_structure Rats Inbred Lew Antibody Formation Immunology biology.protein Parasitology Antibody medicine.drug |
| Zdroj: | International Journal for Parasitology. 6:103-106 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/0020-7519(76)90063-1 |
| Popis: | Both normal and immune spleen cells transferred to clean, syngeneic recipient rats induce an accelerated antibody response to challenge infection. However, only the immune spleen cells induce marked protection against challenge with viable P. berghei parasites. Pretreatment of the normal or immune donor rats with cyclophosphamide markedly depletes their spleens. However, such pretreatment affects neither the fluorescent antibody response to challenge in the recipient rats nor the protection-inducing potential of the residual spleen cell population. |
| Databáze: | OpenAIRE |
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