Serum anti-mullerian hormone levels in healthy females: a nomogram ranging from infancy to adulthood
| Autor: | A.C.S. Hokken-Koelega, Eva Maria Roes, S. Lie Fong, Inger B. Schipper, Corrine K. Welt, A. P. N. Themmen, Marinus J.C. Eijkemans, Jenny A. Visser, Bart C.J.M. Fauser, Y. B. de Rijke, F. H. De Jong, Frank J.M. Broekmans, Wilbert H.M. Peters, Joop S.E. Laven |
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| Přispěvatelé: | Obstetrics & Gynecology, Internal Medicine, Clinical Chemistry, Public Health, Pediatrics |
| Rok vydání: | 2012 |
| Předmět: |
Anti-Mullerian Hormone
Aging endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Cohort Studies Follicle-stimulating hormone Endocrinology Reference Values Young adult Child media_common biology Anti-Müllerian hormone Middle Aged female genital diseases and pregnancy complications Menopause Health Child Preschool Cohort Female Molecular gastro-enterology and hepatology Translational research [IGMD 2] hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty endocrine system Adolescent DCN MP - Plasticity and memory media_common.quotation_subject Context (language use) Diagnostic Techniques Endocrine Young Adult Internal medicine medicine Humans Endocrine Research Ovarian reserve Diagnostic Techniques Obstetrical and Gynecological Menstrual Cycle Menstrual cycle business.industry urogenital system Biochemistry (medical) Infant Newborn Infant medicine.disease Nomograms biology.protein business Biomarkers |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 97, 4650-5 Journal of Clinical Endocrinology and Metabolism, 97, 12, pp. 4650-5 Journal of Clinical Endocrinology and Metabolism, 97(12), 4650-4655. Endocrine Society |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.2012-1440 |
| Popis: | Item does not contain fulltext Context: Anti-Mullerian hormone (AMH) is an accurate marker of ovarian reserve. However, sufficiently large sets of normative data from infancy to the end of reproductive life are scarce. Objective: This study was an assessment of serum AMH levels in healthy females. Subjects: In 804 healthy females ranging from infancy until the end of the reproductive period, serum AMH levels were measured with an enzyme-linked immunometric assay. All adults had regular menstrual cycles. The majority was proven fertile and none of them had used oral contraceptive pills prior to study inclusion. Results: In the total cohort, AMH was inversely correlated with age (r = -0.24; P < 0.001). The age at which the maximum AMH value was attained was at 15.8 yr. In girls younger than 15.8 yr, serum AMH and age were positively correlated (r = +0.18; P = 0.007). Thereafter AMH levels remained stable (r = -0.33; P = 0.66), whereas from the age of 25.0 yr onward, an inverse correlation between AMH and age (r = -0.47; P < 0.001) was observed. At any given age, considerable interindividual differences in serum AMH levels were observed. Conclusion: During infancy AMH levels increase, whereas during adolescence, a plateau until the age of 25 yr was observed. From the age of 25 yr onward, serum AMH levels correlate inversely with age, implying that AMH is applicable as a marker of ovarian reserve only in women of 25 yr old and older. Our nomogram may facilitate counseling women on their reproductive potential. |
| Databáze: | OpenAIRE |
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