Visible-Light-Mediated Nucleophilic Addition of an α-Aminoalkyl Radical to Isocyanate or Isothiocyanate
Autor: | Pixu Li, Ping Lu, Xiangyong Gu, Hongxia Zhou |
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Rok vydání: | 2013 |
Předmět: | |
Zdroj: | Organic Letters. 15:5646-5649 |
ISSN: | 1523-7052 1523-7060 |
DOI: | 10.1021/ol402573j |
Popis: | A visible-light photoredox synthesis of α-amino amide or α-amino thioamide from N,N-dimethylaniline derivatives and aryl isocyanate or aryl isothiocyanate was developed. Bis[2-(4,6-difluorophenyl)pyridinato-C(2),N](picolinato)iridium(III) (FIrpic) was found to be the effective catalyst among six catalysts screened. The reaction involves generation of α-aminoalkyl radicals from tertiary amines, followed by radical addition to the electron-deficient carbon of isocyanate and isothiocyanate. |
Databáze: | OpenAIRE |
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