Visible-Light-Mediated Nucleophilic Addition of an α-Aminoalkyl Radical to Isocyanate or Isothiocyanate

Autor:	Pixu Li, Ping Lu, Xiangyong Gu, Hongxia Zhou
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Nucleophilic addition Aryl Radical Organic Chemistry Biochemistry Isocyanate Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Amide Isothiocyanate Organic chemistry Physical and Theoretical Chemistry Thioamide
Zdroj:	Organic Letters. 15:5646-5649
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol402573j
Popis:	A visible-light photoredox synthesis of α-amino amide or α-amino thioamide from N,N-dimethylaniline derivatives and aryl isocyanate or aryl isothiocyanate was developed. Bis[2-(4,6-difluorophenyl)pyridinato-C(2),N](picolinato)iridium(III) (FIrpic) was found to be the effective catalyst among six catalysts screened. The reaction involves generation of α-aminoalkyl radicals from tertiary amines, followed by radical addition to the electron-deficient carbon of isocyanate and isothiocyanate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c68fb4a01a294a369656202726e58 https://doi.org/10.1021/ol402573j Zobrazit plný text záznamu