Truncated dopamine transporter's epigenetics: Heterozigosity of the grandmother rat temperates the vulnerable phenotype in second‐generation offspring

Autor: Martina Pepe, Barbara Calcaprina, Francesca Vaquer, Giovanni Laviola, Walter Adriani
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Developmental Neuroscience. 82:168-179
ISSN: 1873-474X
0736-5748
DOI: 10.1002/jdn.10172
Popis: Behavioral phenotype differs among epigenotypes of dopamine-transporter heterozygous (DAT-HET) rats. Epigenetic regulations act through transgenerational effects, referring to phenotypic variations emerging at second or third generation. To investigate transgenerational influences exerted by maternal grandmothers, we developed breeding schemes where only the genotype of maternal grandmothers varied. HET females, to serve as MAT vs. MIX mothers, were generated, respectively, from WT × KO = MAT and MAT × KO = MIX breeding, with KO males acting as grandfather. The HET experimental groups, generated from either MAT or MIX mothers, were called MIX-by-MAT and MIX
Databáze: OpenAIRE
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