Truncated dopamine transporter's epigenetics: Heterozigosity of the grandmother rat temperates the vulnerable phenotype in second‐generation offspring

Autor:	Martina Pepe, Barbara Calcaprina, Francesca Vaquer, Giovanni Laviola, Walter Adriani
Rok vydání:	2022
Předmět:	Male Dopamine Plasma Membrane Transport Proteins Heterozygote Phenotype Developmental Neuroscience Dopamine Animals Female Epigenesis Genetic Rats Developmental Biology
Zdroj:	International Journal of Developmental Neuroscience. 82:168-179
ISSN:	1873-474X 0736-5748
Popis:	Behavioral phenotype differs among epigenotypes of dopamine-transporter heterozygous (DAT-HET) rats. Epigenetic regulations act through transgenerational effects, referring to phenotypic variations emerging at second or third generation. To investigate transgenerational influences exerted by maternal grandmothers, we developed breeding schemes where only the genotype of maternal grandmothers varied. HET females, to serve as MAT vs. MIX mothers, were generated, respectively, from WT × KO = MAT and MAT × KO = MIX breeding, with KO males acting as grandfather. The HET experimental groups, generated from either MAT or MIX mothers, were called MIX-by-MAT and MIX
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7c0fb0d4f016be49df1f2a1649b2b8 https://doi.org/10.1002/jdn.10172 Zobrazit plný text záznamu Plný text