Phenotypic and genotypic characteristics of the human prothymocyte
| Autor: | J. J. M. Van Dongen, W. M. Comans-Bitter |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Genetics
Antigens Differentiation T-Lymphocyte CD3 Complex Genotype Cellular differentiation CD3 T-Lymphocytes Immunology Receptors Antigen T-Cell chemical and pharmacologic phenomena Cell Differentiation Biology Hematopoietic Stem Cells Phenotype Germline Terminal deoxynucleotidyl transferase DNA Nucleotidylexotransferase T cell differentiation biology.protein Humans Gene |
| Zdroj: | Immunologic research. 6(4) |
| ISSN: | 0257-277X |
| Popis: | Based on the data discussed here, we postulate that the human prothymocyte has the TdT+/HLA-DR+/CD7+/CD2+/CD5-/CD1-/CD3- phenotype and occurs in the BM in low frequencies (about 2 in 10,000 MNC). The TcR-Γ and TcR-β genes of the prothymocyte are in germline configuration. However, the CD3 genes are transcribed and probably CyCD3 is expressed (cf. Fig. 3). Future experiments have to elucidate which signals and proteins regulate the migration patterns and differentiation pathways of prothymocytes. Furthermore, the role of CyCD3 during the early stages of T cell differentiation has to be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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