Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice
| Autor: | Katharina Gryksa, Peter J. Flor, Angelika Bauer, Daniel Peterlik, Laura A. Mittmann, Nicole Uschold-Schmidt, Oliver J. Bosch |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Agonist medicine.medical_specialty medicine.drug_class Receptor expression Hippocampus Prefrontal Cortex Biology Receptors Metabotropic Glutamate 590 Tiere (Zoologie) 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Glutamatergic Mice 0302 clinical medicine AMN082 Internal medicine Genetics medicine Animals Excitatory Amino Acid Agents Benzhydryl Compounds Maternal Behavior Motivation Glutamate receptor MEDIAL PREFRONTAL CORTEX NUCLEUS-ACCUMBENS OLFACTORY BULBECTOMY BEHAVIOR RAT STRESS LOCALIZATION AGONIST BRAIN ACTIVATION knockout metabotropic glutamate receptor social behavior spontaneous maternal behavior strain difference XAP044 Aggression Mice Inbred C57BL 030104 developmental biology Endocrinology Neurology chemistry Metabotropic glutamate receptor Chromones Knockout mouse ddc:590 Female 030217 neurology & neurosurgery |
| Zdroj: | Genes, brain, and behaviorREFERENCES. 19(1) |
| ISSN: | 1601-183X |
| Popis: | The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate expression of maternal behavior is essential for successful rearing and healthy development of the young. By understanding genetic and neural mechanisms underlying this important prosocial behavior, we gain valuable insights into possible dysregulations. Using genetic ablation as well as pharmacological modulation, we studied various parameters of maternal behavior in two different mouse strains under the influence of mGlu7. We can clearly show a regulatory role of mGlu7 in maternal behavior. Naive virgin female C57BL/6 mGlu7 knockout mice showed more often nursing postures and less spontaneous maternal aggression compared to their heterozygous and wildtype littermates. In lactating C57BL/6 wildtype mice, acute central activation of mGlu7 by the selective agonist AMN082 reduced arched back nursing and accelerated pup retrieval without affecting maternal aggression. In addition, in lactating CD1 wildtype mice the selective mGlu7 antagonist XAP044 increased both pup retrieval and maternal aggression. With respect to receptor expression levels, mGlu7 mRNA expression was higher in lactating vs virgin C57BL/6 mice in the prefrontal cortex, but not hypothalamus or hippocampus. In conclusion, these findings highlight a significant role of the mGlu7 receptor subtype in mediating maternal behavior in mice. Region-dependent studies are warranted to further extend our knowledge on the specific function of the brain glutamate system in maternal behavior. |
| Databáze: | OpenAIRE |
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