Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice

Autor: Katharina Gryksa, Peter J. Flor, Angelika Bauer, Daniel Peterlik, Laura A. Mittmann, Nicole Uschold-Schmidt, Oliver J. Bosch
Rok vydání: 2019
Předmět:
0301 basic medicine
Agonist
medicine.medical_specialty
medicine.drug_class
Receptor expression
Hippocampus
Prefrontal Cortex
Biology
Receptors
Metabotropic Glutamate
590 Tiere (Zoologie)
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Glutamatergic
Mice
0302 clinical medicine
AMN082
Internal medicine
Genetics
medicine
Animals
Excitatory Amino Acid Agents
Benzhydryl Compounds
Maternal Behavior
Motivation
Glutamate receptor
MEDIAL PREFRONTAL CORTEX
NUCLEUS-ACCUMBENS
OLFACTORY BULBECTOMY
BEHAVIOR
RAT
STRESS
LOCALIZATION
AGONIST
BRAIN
ACTIVATION
knockout
metabotropic glutamate receptor
social behavior
spontaneous maternal behavior
strain difference
XAP044
Aggression
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Neurology
chemistry
Metabotropic glutamate receptor
Chromones
Knockout mouse
ddc:590
Female
030217 neurology & neurosurgery
Zdroj: Genes, brain, and behaviorREFERENCES. 19(1)
ISSN: 1601-183X
Popis: The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate expression of maternal behavior is essential for successful rearing and healthy development of the young. By understanding genetic and neural mechanisms underlying this important prosocial behavior, we gain valuable insights into possible dysregulations. Using genetic ablation as well as pharmacological modulation, we studied various parameters of maternal behavior in two different mouse strains under the influence of mGlu7. We can clearly show a regulatory role of mGlu7 in maternal behavior. Naive virgin female C57BL/6 mGlu7 knockout mice showed more often nursing postures and less spontaneous maternal aggression compared to their heterozygous and wildtype littermates. In lactating C57BL/6 wildtype mice, acute central activation of mGlu7 by the selective agonist AMN082 reduced arched back nursing and accelerated pup retrieval without affecting maternal aggression. In addition, in lactating CD1 wildtype mice the selective mGlu7 antagonist XAP044 increased both pup retrieval and maternal aggression. With respect to receptor expression levels, mGlu7 mRNA expression was higher in lactating vs virgin C57BL/6 mice in the prefrontal cortex, but not hypothalamus or hippocampus. In conclusion, these findings highlight a significant role of the mGlu7 receptor subtype in mediating maternal behavior in mice. Region-dependent studies are warranted to further extend our knowledge on the specific function of the brain glutamate system in maternal behavior.
Databáze: OpenAIRE
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