Shear wave elastography findings in Immunoglobulin A Nephropathy patients: is it more specific and sensitive for interstitial fibrosis or interstitial fibrosis/tubular atrophy?
| Autor: | Esra Dolarslan, Ahmet Kiykim, Yüksel Balcı, İclal Gürses, Yasemin Yuyucu Karabulut, Serap Demir, Kenan Turgutalp, Simge Bardak, Caner Özer, İlter Helvacı |
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| Přispěvatelé: | İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Immunoglobulin A
Adult Male Pathology medicine.medical_specialty Immunoglobulin A Nephropathy Tubular atrophy 030232 urology & nephrology Young’s Elastic Modulus 030204 cardiovascular system & hematology Interstitial fibrosis urologic and male genital diseases Critical Care and Intensive Care Medicine lcsh:RC870-923 Sensitivity and Specificity Annual incidence Young's Elastic Modulus 03 medical and health sciences 0302 clinical medicine Elastic Modulus medicine Humans Prospective Studies shear waveelastography Shear wave elastography biology interstitial fibrosis business.industry Glomerulonephritis IGA General Medicine Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology Fibrosis Kidney Tubules Nephrology Case-Control Studies biology.protein Clinical Study Elasticity Imaging Techniques Female Atrophy business Kidney disease Research Article |
| Zdroj: | Renal Failure article-version (VoR) Version of Record Renal Failure, Vol 42, Iss 1, Pp 590-599 (2020) |
| DOI: | 10.1080/0886022X.2020.1779087 |
| Popis: | WOS:000544516800001 PubMed ID: 32597278 Background:Prediction of prognosis in Immunoglobulin A Nephropathy (IgAN) and taking appropriate precautions may reduce annual incidence of chronic kidney disease. This may be possible by close follow-up for the development and progression of interstitial fibrosis (IF) or interstitial fibrosis/tubular atrophy (IFTA) in IgAN patients. Aim:To investigate whether Young's elastic modulus (YM) which measured shear wave elastography (SWE) might be used for follow-up of IF or IFTA in IgAN patients. Methods:Prospective study was approved by Human Research Ethics Committee. Group 1 consisted of patients with IgAN. Group 2 consisted of healthy control participants. Young's elastic modulus which is a value of stiffness along with longitudinal stiffness was used to evaluate tissue elasticity. Specificity, sensitivity, positive predictive value (PPV) of YM for the presence of IF and IFTA were evaluated. Results:Group 1 consisted of 30 participants, and group 2 consisted of 32 participants. Sensitivity and specificity of SWE to diagnose presence of IF for YM > 15 kPa were 89% and 90%, respectively. PPV among the ones whom IF was diagnosed by YM >15 kPa was 91%. Sensitivity and specificity of SWE to diagnose presence of IFTA for YM > 15 were 65% and 51%, respectively. PPV among the ones whom IFTA was diagnosed by YM >15 kPa was 78.1%. Conclusions:YM which measured SWE is highly specific and sensitive in the diagnosis of IF, but not for IFTA in IgAN patients. Therefore, progression for IF in IgAN may be followed by SWE. |
| Databáze: | OpenAIRE |
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