Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles

Autor: Mary Anne S. Melo, Hockin H.K. Xu, Rashed AlSahafi, Maria Salem Ibrahim, Michael D. Weir, Heba Mitwalli, Abdulrahman A. Balhaddad, Thomas W. Oates
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nanomaterials
Nanomaterials, Vol 10, Iss 2001, p 2001 (2020)
Volume 10
Issue 10
ISSN: 2079-4991
Popis: Oral biofilm accumulation at the tooth&ndash
restoration interface often leads to recurrent dental caries and restoration failure. The objectives of this study were to: (1) develop a novel bioactive crown cement containing dimethylaminohexadecyl methacrylate (DMAHDM) and nano-sized amorphous calcium phosphate (NACP), and (2) investigate the mechanical properties, anti-biofilm activity, and calcium (Ca2+) and phosphate (PO43&minus
) ion release of the crown cement for the first time. The cement matrix consisted of pyromellitic glycerol dimethacrylate and ethoxylated bisphenol-A dimethacrylate monomers and was denoted PEHB resin matrix. The following cements were tested: (1) RelyX luting cement (commercial control)
(2) 55% PEHB + 45% glass fillers (experimental control)
(3) 55% PEHB + 20% glass + 25% NACP + 0% DMAHDM
(4) 52% PEHB + 20% glass + 25% NACP + 3% DMAHDM
(5) 51% PEHB + 20% glass + 25% NACP + 4% DMAHDM
(6) 50% PEHB + 20% glass + 25% NACP + 5% DMAHDM. Mechanical properties and ion release were measured. Streptococcusmutans (S. mutans) biofilms were grown on cements, and colony-forming units (CFUs) and other biofilm properties were measured. The novel bioactive cement demonstrated strong antibacterial properties and high levels of Ca2+ and PO43&minus
ion release to remineralize tooth lesions. Adding NACP and DMAHDM into the cement did not adversely affect the mechanical properties and dentin bonding strength. In conclusion, the novel NACP + DMAHDM crown cement has excellent potential for restoration cementation to inhibit caries by suppressing oral biofilm growth and increasing remineralization via Ca2+ and PO43&minus
ions. The NACP + DMAHDM composition may have wide applicability to other biomaterials to promote hard-tissue formation and combat bacterial infection.
Databáze: OpenAIRE
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