Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles
| Autor: | Mary Anne S. Melo, Hockin H.K. Xu, Rashed AlSahafi, Maria Salem Ibrahim, Michael D. Weir, Heba Mitwalli, Abdulrahman A. Balhaddad, Thomas W. Oates |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
chemistry.chemical_element 02 engineering and technology Calcium Methacrylate Streptococcus mutans Article lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system calcium phosphate nanoparticles Dentin medicine General Materials Science Amorphous calcium phosphate Cement biology oral biofilms 030206 dentistry biochemical phenomena metabolism and nutrition 021001 nanoscience & nanotechnology Phosphate biology.organism_classification crown cement stomatognathic diseases Monomer medicine.anatomical_structure chemistry lcsh:QD1-999 dental caries antibacterial monomer 0210 nano-technology Nuclear chemistry |
| Zdroj: | Nanomaterials Nanomaterials, Vol 10, Iss 2001, p 2001 (2020) Volume 10 Issue 10 |
| ISSN: | 2079-4991 |
| Popis: | Oral biofilm accumulation at the tooth&ndash restoration interface often leads to recurrent dental caries and restoration failure. The objectives of this study were to: (1) develop a novel bioactive crown cement containing dimethylaminohexadecyl methacrylate (DMAHDM) and nano-sized amorphous calcium phosphate (NACP), and (2) investigate the mechanical properties, anti-biofilm activity, and calcium (Ca2+) and phosphate (PO43&minus ) ion release of the crown cement for the first time. The cement matrix consisted of pyromellitic glycerol dimethacrylate and ethoxylated bisphenol-A dimethacrylate monomers and was denoted PEHB resin matrix. The following cements were tested: (1) RelyX luting cement (commercial control) (2) 55% PEHB + 45% glass fillers (experimental control) (3) 55% PEHB + 20% glass + 25% NACP + 0% DMAHDM (4) 52% PEHB + 20% glass + 25% NACP + 3% DMAHDM (5) 51% PEHB + 20% glass + 25% NACP + 4% DMAHDM (6) 50% PEHB + 20% glass + 25% NACP + 5% DMAHDM. Mechanical properties and ion release were measured. Streptococcusmutans (S. mutans) biofilms were grown on cements, and colony-forming units (CFUs) and other biofilm properties were measured. The novel bioactive cement demonstrated strong antibacterial properties and high levels of Ca2+ and PO43&minus ion release to remineralize tooth lesions. Adding NACP and DMAHDM into the cement did not adversely affect the mechanical properties and dentin bonding strength. In conclusion, the novel NACP + DMAHDM crown cement has excellent potential for restoration cementation to inhibit caries by suppressing oral biofilm growth and increasing remineralization via Ca2+ and PO43&minus ions. The NACP + DMAHDM composition may have wide applicability to other biomaterials to promote hard-tissue formation and combat bacterial infection. |
| Databáze: | OpenAIRE |
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