Epstein-Barr Virus Associated Smooth Muscle Tumors in Post Transplant Pediatric Patients Two Cases of Rare Locations, and Review of the Literature

Autor: Carlos R. Abramowsky, Nancy Elawabdeh, Maaman Z. Bashir, David M. Wrubel, Brent M. Cone, Hans E. Grossniklaus, Bahig M. Shehata, Joseph D. Walrath
Rok vydání: 2013
Předmět:
Zdroj: Fetal and Pediatric Pathology. 32:184-191
ISSN: 1551-3823
1551-3815
DOI: 10.3109/15513815.2012.701265
Popis: Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.
Databáze: OpenAIRE
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Popis
Abstrakt:Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.
ISSN:15513823
15513815
DOI:10.3109/15513815.2012.701265