In vivo demonstration of focal fibrinolytic activity in abdominal aortic aneurysms
| Autor: | Niels Tromholt, Svend Juul Jørgensen, Mogens Sandbjerg Hansen, Birger Hesse |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Fibrin Aortic aneurysm Aneurysm Internal medicine medicine.artery Fibrinolysis medicine Humans Aorta Abdominal cardiovascular diseases Aged Disseminated intravascular coagulation Aorta biology business.industry Indium Radioisotopes Proteolytic enzymes Disseminated Intravascular Coagulation Middle Aged medicine.disease Abdominal aortic aneurysm Radioimmunodetection Tissue Plasminogen Activator cardiovascular system Cardiology biology.protein Female Cardiology and Cardiovascular Medicine business Aortic Aneurysm Abdominal |
| Zdroj: | European Journal of Vascular Surgery. 7:675-679 |
| ISSN: | 0950-821X |
| DOI: | 10.1016/s0950-821x(05)80715-7 |
| Popis: | Disseminated intravascular coagulation in association with arterial aneurysm has been reported in several cases. Reports have suggested a continuous deposition of fibrin and/or platelets at the site of the aneurysm followed by fibrinolysis as responsible for this disorder. To further investigate this theory we studied the in vivo binding of an indium-111-labelled monoclonal antibody against human tissue plasminogen activator (t-PA), a proteolytic enzyme involved in the fibrinolysis. Six patients admitted to the hospital for elective resection of an abdominal aortic aneurysm with a mural thrombus were examined. One day before the operation the antibody was injected intravenously. Scintigrams acquired just prior to operation and tissue samples obtained at the operation revealed an increased t-PA accumulation in the wall of the aneurysm. The study demonstrates in vivo, focally increased fibrinolytic activity in the aneurysm, explaining the coagulopathy observed in these patients. |
| Databáze: | OpenAIRE |
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