Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration
| Autor: | Kim Lauper, Michele Iudici, Denis Mongin, Sytske Anne Bergstra, Denis Choquette, Catalin Codreanu, René Cordtz, Diederik De Cock, Lene Dreyer, Ori Elkayam, Ellen-Margrethe Hauge, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Nevsun Inanc, Lianne Kearsley-Fleet, Eirik Klami Kristianslund, Tore K Kvien, Burkhard F Leeb, Galina Lukina, Dan C Nordström, Karel Pavelka, Manuel Pombo-Suarez, Ziga Rotar, Maria Jose Santos, Anja Strangfeld, Patrick Verschueren, Delphine Sophie Courvoisier, Axel Finckh |
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| Přispěvatelé: | HUS Internal Medicine and Rehabilitation, Department of Medicine, Clinicum, University of Helsinki, Reumatologian yksikkö, Lauper K., Ludici M., Mongin D., Bergstra S. A., Choquette D., Codreanu C., Cordtz R., De Cock D., Dreyer L., Elkayam O., et al., Public Health Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Internal Diseases
Epidemiology MONOTHERAPY MULTICENTER Antirheumatic Agents/therapeutic use Sağlık Bilimleri İmmünoloji ve Romatoloji İç Hastalıkları Clinical Medicine (MED) Arthritis Rheumatoid DOUBLE-BLIND Rheumatoid PLUS METHOTREXATE Immunology and Allergy Klinik Tıp (MED) ROMATOLOJİ Klinik Tıp PLACEBO Tıp Biological Therapy Treatment Outcome Antirheumatic Agents Medicine Romatoloji Life Sciences & Biomedicine Immunology Therapeutics General Biochemistry Genetics and Molecular Biology Immunology and Rheumatology Abatacept Rheumatology Health Sciences INFLIXIMAB Humans Janus Kinase Inhibitors Arthritis Rheumatoid/chemically induced Science & Technology Internal Medicine Sciences Interleukin-6 Tumor Necrosis Factor-alpha Arthritis Janus Kinase Inhibitors/therapeutic use NECROSIS-FACTOR-ALPHA Dahili Tıp Bilimleri CLINICAL MEDICINE PHASE-III TOFACITINIB Abatacept/therapeutic use 3121 General medicine internal medicine and other clinical medicine Tumor Necrosis Factor Inhibitors ADALIMUMAB |
| Zdroj: | Annals of the Rheumatic Diseases, 81(10). BMJ PUBLISHING GROUP Lauper, K, Hyrich, K L, Kearsley-Fleet, L & et al. 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31,846 patients with rheumatoid arthritis in 19 registers from the “JAK-pot” collaboration ', Annals of the rheumatic diseases . https://doi.org/10.1136/annrheumdis-2022-222586 Lauper, K, Ludici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E-M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, 222586, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586 Lauper, K, Iudici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586 |
| DOI: | 10.1136/annrheumdis-2022-222586 |
| Popis: | BackgroundJAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since JAKi approval, in an international collaboration of 19 registers.MethodsIn this observational cohort study, patients initiating tumour necrosis factor inhibitors (TNFi), interleukin-6 inhibitors (IL-6i), abatacept (ABA) or JAKi were included. We compared the effectiveness of these treatments in terms of drug discontinuation and Clinical Disease Activity Index (CDAI) response rates at 1 year. Analyses were adjusted for patient, disease and treatment characteristics, including lines of therapy and accounted for competing risk.ResultsWe included 31 846 treatment courses: 17 522 TNFi, 2775 ABA, 3863 IL-6i and 7686 JAKi. Adjusted analyses of overall discontinuation were similar across all treatments. The main single reason of stopping treatment was ineffectiveness. Compared with TNFi, JAKi were less often discontinued for ineffectiveness (adjusted HR (aHR) 0.75, 95% CI 0.67 to 0.83), as was IL-6i (aHR 0.76, 95% CI 0.67 to 0.85) and more often for adverse events (aHR 1.16, 95% CI 1.03 to 1.33). Adjusted CDAI response rates at 1 year were similar between TNFi, JAKi and IL-6i and slightly lower for ABA.ConclusionThe adjusted overall drug discontinuation and 1 year response rates of JAKi and IL-6i were similar to those observed with TNFi. Compared with TNFi, JAKi were more often discontinued for adverse events and less for ineffectiveness, as were IL-6i. |
| Databáze: | OpenAIRE |
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