Therapygenetics: 5-HTTLPR genotype predicts the response to exposure therapy for agoraphobia

Autor: Thea Overbeek, Gabriel Esquivel, Gunter Kenis, Nicole Leibold, Koen Schruers, Inge Knuts, Lies Goossens
Přispěvatelé: Psychiatrie & Neuropsychologie, MUMC+: MA Niet Med Staf Psychiatrie (9), Promovendi MHN, RS: MHeNs - R2 - Mental Health
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: European Neuropsychopharmacology, 24(8), 1222-1228. Elsevier
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2014.05.007
Popis: This study was intended to assess the extent to which the low-expression allele of the serotonin transporter gene promoter predicts better response to exposure-based behavior therapy in patients with panic disorder with agoraphobia (PDA). Ninety-nine patients with PDA underwent a 1-week in vivo exposure-based behavior therapy program and provided saliva samples to extract genomic DNA and classify individuals according to four allelic forms (S-A, S-G, L-A, L-G) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in avoidance behavior in PDA following treatment. After controlling for pre-treatment avoidance behavior, the 5-HTTLPR low-expression genotypes showed a more favorable response to exposure therapy two weeks following treatment, compared to the other patients. This study suggests a genetic contribution to treatment outcome following behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PDA.
Databáze: OpenAIRE
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