Therapygenetics: 5-HTTLPR genotype predicts the response to exposure therapy for agoraphobia
| Autor: | Thea Overbeek, Gabriel Esquivel, Gunter Kenis, Nicole Leibold, Koen Schruers, Inge Knuts, Lies Goossens |
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| Přispěvatelé: | Psychiatrie & Neuropsychologie, MUMC+: MA Niet Med Staf Psychiatrie (9), Promovendi MHN, RS: MHeNs - R2 - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Serotonin Genotype Panic Disorder with Agoraphobia medicine.medical_treatment Exposure therapy Implosive Therapy Gene Frequency Internal medicine mental disorders medicine Genetics Humans Pharmacology (medical) Genetic Testing Promoter Regions Genetic Somatoform Disorders Allele frequency Agoraphobia Biological Psychiatry Serotonin transporter Psychiatric Status Rating Scales Serotonin Plasma Membrane Transport Proteins Pharmacology Analysis of Variance Polymorphism Genetic Panic disorder biology Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome Neurology Behavior therapy 5-HTTLPR biology.protein Female Neurology (clinical) Psychology Clinical psychology |
| Zdroj: | European Neuropsychopharmacology, 24(8), 1222-1228. Elsevier |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2014.05.007 |
| Popis: | This study was intended to assess the extent to which the low-expression allele of the serotonin transporter gene promoter predicts better response to exposure-based behavior therapy in patients with panic disorder with agoraphobia (PDA). Ninety-nine patients with PDA underwent a 1-week in vivo exposure-based behavior therapy program and provided saliva samples to extract genomic DNA and classify individuals according to four allelic forms (S-A, S-G, L-A, L-G) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in avoidance behavior in PDA following treatment. After controlling for pre-treatment avoidance behavior, the 5-HTTLPR low-expression genotypes showed a more favorable response to exposure therapy two weeks following treatment, compared to the other patients. This study suggests a genetic contribution to treatment outcome following behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PDA. |
| Databáze: | OpenAIRE |
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