Stereoselective intramolecular cycloadditions of homochiral nitrilimines: synthesis of enantiopure (6S)-substituted-2,3,3a,4,5,6-hexahydro-furo[3,4-c]pyrazoles

Autor:	Lara De Benassuti, Luisa Garanti, Giorgio Molteni
Rok vydání:	2004
Předmět:	Inorganic Chemistry Enantiopure drug Chemistry Stereochemistry Intramolecular force Organic Chemistry Stereoselectivity Physical and Theoretical Chemistry Catalysis
Zdroj:	Tetrahedron: Asymmetry. 15:1127-1131
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2004.02.002
Popis:	Starting from (S)-ethyl lactate and (S)-ethyl mandelate the homochiral hydrazonoyl chlorides 4b–d have been synthesised. Their base treatment promoted the in situ generation of the corresponding nitrilimines 5b–d, which gave the enantiopure title compounds with good overall yields and diastereoselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f61dd043b26b31ce83442670982de136 https://doi.org/10.1016/j.tetasy.2004.02.002 Zobrazit plný text záznamu Full Text from ScienceDirect