Stereoselective intramolecular cycloadditions of homochiral nitrilimines: synthesis of enantiopure (6S)-substituted-2,3,3a,4,5,6-hexahydro-furo[3,4-c]pyrazoles
Autor: | Lara De Benassuti, Luisa Garanti, Giorgio Molteni |
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Rok vydání: | 2004 |
Předmět: | |
Zdroj: | Tetrahedron: Asymmetry. 15:1127-1131 |
ISSN: | 0957-4166 |
DOI: | 10.1016/j.tetasy.2004.02.002 |
Popis: | Starting from (S)-ethyl lactate and (S)-ethyl mandelate the homochiral hydrazonoyl chlorides 4b–d have been synthesised. Their base treatment promoted the in situ generation of the corresponding nitrilimines 5b–d, which gave the enantiopure title compounds with good overall yields and diastereoselectivities. |
Databáze: | OpenAIRE |
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