Synthesis of some 4-substituted 1-[(2-hydroxyethoxy)methyl]-pyrazolo[3,4-d]pyrimidines

Autor: J. L. Barascut, M. L. Taha, Hassan B. Lazrek, Jean Louis Imbach
Rok vydání: 2010
Předmět:
Zdroj: Bulletin des Sociétés Chimiques Belges. 105:279-285
ISSN: 0037-9646
DOI: 10.1002/bscb.19961050510
Popis: A number of 4-substituted pyrazolo[3,4-d]pyrimidines 1a-f has been coupled with (2-acetoxyethoxy)methylbromide 2, using liquid-liquid and solid-liquid phase transfer catalysis. The influence of the solvent and catalyst has been studied. The N1 isomers have been regioselectively formed in a fairly good yields. All compounds 4a-h have been evaluated against HIV and various DNA viruses and they have been found to be inactive.
Databáze: OpenAIRE