| Autor: |
Silvio Spadari, F. Focher, G. Biamonti, Paolo Mazzarello, A. Verri |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Biology of Aging ISBN: 9783540544883 |
| DOI: |
10.1007/978-3-642-85789-8_2 |
| Popis: |
Several hypotheses have been proposed to explain the molecular mechanisms of aging. Common to some of these hypotheses is that aging is the result of an accumulation of stochastic damage to DNA [16]. Damaged DNA is continuously repaired by several mechanisms in both proliferating and resting cells in order to avoid defective replication and abnormalities in transcription and translation [7]. One sort of such damage is the presence of uracil in DNA, deriving either from spontaneous or induced deamination of cytosine to uracil [7] or from uracil misincorporation during DNA replication in place of thymine (Fig. 1), as has been described in some viruses, bacteria, and cultured human lymphocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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