Phosphodisulfide bond: A new linker for the oligonucleotide conjugation

Autor:	Marcel Chassignol, N.T. Thuong
Rok vydání:	1998
Předmět:	chemistry.chemical_compound chemistry Oligonucleotide Organic Chemistry Drug Discovery food and beverages Biochemistry Linker Combinatorial chemistry Thiophosphate
Zdroj:	Tetrahedron Letters. 39:8271-8274
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01854-1
Popis:	Oligonucleotide thiophosphates react with 2-pyridyl-disulfide derivatives to give phosphodisulfide which can, upon reduction, be easily cleaved to give the starting oligonucleotide with a terminal thiophosphate group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2ac68142c7835ccafe6ff2f74a5e989 https://doi.org/10.1016/s0040-4039(98)01854-1 Zobrazit plný text záznamu Full Text from ScienceDirect