Phosphodisulfide bond: A new linker for the oligonucleotide conjugation

Autor: Marcel Chassignol, N.T. Thuong
Rok vydání: 1998
Předmět:
Zdroj: Tetrahedron Letters. 39:8271-8274
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01854-1
Popis: Oligonucleotide thiophosphates react with 2-pyridyl-disulfide derivatives to give phosphodisulfide which can, upon reduction, be easily cleaved to give the starting oligonucleotide with a terminal thiophosphate group.
Databáze: OpenAIRE