The application of vinylogous iminium salt derivatives to an efficient relay synthesis of the pyrrole containing alkaloids polycitone A and B
Autor: | Bret R. Adams, Robert B. Miller, Daniel W. Callahan, Nicholas E. Lauerman, Karen X. Du, Edith J. Banner, James A. Sikorski, John T. Gupton, Stuart C. Clough, Keith Krumpe, Kartik M. Keertikar, Barrett A. Little, John M. Solano, Austin B. Scharf, Rene P.F. Kanters |
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Rok vydání: | 2005 |
Předmět: | |
Zdroj: | Tetrahedron. 61:1845-1854 |
ISSN: | 0040-4020 |
DOI: | 10.1016/j.tet.2004.12.015 |
Popis: | A new and efficient relay synthesis of the marine natural products polycitone A and B is described. The new strategy relies on the formation of 2,4-disubstituted pyrroles from a vinamidinium salt followed by electrophilic substitution at the 5-position of the pyrrole and Suzuki coupling at the 4-position to produce the tetrasubstituted heterocycle efficiently and with complete control of regiochemistry. |
Databáze: | OpenAIRE |
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