The application of vinylogous iminium salt derivatives to an efficient relay synthesis of the pyrrole containing alkaloids polycitone A and B

Autor:	Bret R. Adams, Robert B. Miller, Daniel W. Callahan, Nicholas E. Lauerman, Karen X. Du, Edith J. Banner, James A. Sikorski, John T. Gupton, Stuart C. Clough, Keith Krumpe, Kartik M. Keertikar, Barrett A. Little, John M. Solano, Austin B. Scharf, Rene P.F. Kanters
Rok vydání:	2005
Předmět:	chemistry.chemical_classification Organic Chemistry Salt (chemistry) Iminium Regioselectivity Biochemistry law.invention Electrophilic substitution chemistry.chemical_compound chemistry Suzuki reaction Relay law Drug Discovery Organic chemistry Pyrrole
Zdroj:	Tetrahedron. 61:1845-1854
ISSN:	0040-4020
DOI:	10.1016/j.tet.2004.12.015
Popis:	A new and efficient relay synthesis of the marine natural products polycitone A and B is described. The new strategy relies on the formation of 2,4-disubstituted pyrroles from a vinamidinium salt followed by electrophilic substitution at the 5-position of the pyrrole and Suzuki coupling at the 4-position to produce the tetrasubstituted heterocycle efficiently and with complete control of regiochemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af83fd1cf6427017468f98a0f0417fa1 https://doi.org/10.1016/j.tet.2004.12.015 Zobrazit plný text záznamu Full Text from ScienceDirect