Drug resin salts of methadone and quinine

Autor:	C.J. de Blaey, R. J. V. D. Broek, L. G. J. De Leede, M. F. H. Zee
Rok vydání:	1979
Předmět:	Pharmacology Drug chemistry.chemical_classification Quinine media_common.quotation_subject Salt (chemistry) chemistry Continuous release Oral administration medicine Pharmacology (medical) medicine.drug media_common Methadone
Zdroj:	Pharmaceutisch weekblad. 1:196-200
ISSN:	1573-739X 0031-6911
DOI:	10.1007/bf02293182
Popis:	A methadone resin salt for oral administration was produced in order to prevent, or at least diminish, the abuse of methadone during a maintenance programme with heroin-addicts. This salt will also lead to a more continuous release of the drug, depending on the cation concentration in the gastrointestinal tract, thus resulting in a more constant plasma level.In vivo andin vitro experiments were performed with various sulphonic acid resin salts of quinine and methadone, in which the quinine salts were used as model substances for the methadone salt.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a5a8a7b60d7062531b56bc6b5581fed1 https://doi.org/10.1007/bf02293182 Zobrazit plný text záznamu