| Autor: |
P. F. Langley, K. R. L. Mansford, D. Smith, J. D. Lewis |
| Rok vydání: |
1966 |
| Předmět: |
|
| Zdroj: |
Biochemical Pharmacology. 15:1821-1829 |
| ISSN: |
0006-2952 |
| DOI: |
10.1016/0006-2952(66)90089-x |
| Popis: |
Spectrophotometric assays indicated that following repeated daily oral dosage, 70 per cent of the poldine methyl methosulphate or its metabolites was excreted in the faeces, while 14 C-poldine methyl methiodide experiments showed significant biliary excretion. After intraperitoneal dosing, Spectrophotometric assays showed that 11 per cent of the compound or its metabolites was excreted in the urine; with 14 C-poldine methyl methiodide 22–36 per cent of the radioactivity appeared in the bile, little appeared in the gastric juice and only a trace in expired CO 2 . Following intravenous dosing a rapid fall-off in blood level was demonstrated with peak liver and kidney levels at 3–5 min; with 14 C-poldine methyl methiodide about 90 per cent of the radioactivity was excreted within 48 hr. Chromatographic/autoradiographic experiments suggested that several metabolites were excreted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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