Biochemical studies on poldine methyl methosulphate
Autor: | P. F. Langley, K. R. L. Mansford, D. Smith, J. D. Lewis |
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Rok vydání: | 1966 |
Předmět: | |
Zdroj: | Biochemical Pharmacology. 15:1821-1829 |
ISSN: | 0006-2952 |
DOI: | 10.1016/0006-2952(66)90089-x |
Popis: | Spectrophotometric assays indicated that following repeated daily oral dosage, 70 per cent of the poldine methyl methosulphate or its metabolites was excreted in the faeces, while 14 C-poldine methyl methiodide experiments showed significant biliary excretion. After intraperitoneal dosing, Spectrophotometric assays showed that 11 per cent of the compound or its metabolites was excreted in the urine; with 14 C-poldine methyl methiodide 22–36 per cent of the radioactivity appeared in the bile, little appeared in the gastric juice and only a trace in expired CO 2 . Following intravenous dosing a rapid fall-off in blood level was demonstrated with peak liver and kidney levels at 3–5 min; with 14 C-poldine methyl methiodide about 90 per cent of the radioactivity was excreted within 48 hr. Chromatographic/autoradiographic experiments suggested that several metabolites were excreted. |
Databáze: | OpenAIRE |
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