Are Drug–Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I

Autor: L. Michele Noles
Rok vydání: 2015
Předmět:
Zdroj: A Case Approach to Perioperative Drug-Drug Interactions ISBN: 9781461474944
DOI: 10.1007/978-1-4614-7495-1_41
Popis: This case discusses a pharmacokinetic interaction between ropivacaine and fluoxetine. Ropivacaine is a cytochrome P450 3A4 and cytochrome 1A2 substrate. Fluoxetine is an inhibitor of both enzymes. Coadministration may result in ropivacaine toxicity.
Databáze: OpenAIRE
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