Are Drug–Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I

Autor:	L. Michele Noles
Rok vydání:	2015
Předmět:	Drug Fluoxetine CYP3A4 business.industry Ropivacaine Local anesthetic medicine.drug_class media_common.quotation_subject Pharmacokinetics Pharmacodynamics Anesthesia Toxicity Medicine business medicine.drug media_common
Zdroj:	A Case Approach to Perioperative Drug-Drug Interactions ISBN: 9781461474944
DOI:	10.1007/978-1-4614-7495-1_41
Popis:	This case discusses a pharmacokinetic interaction between ropivacaine and fluoxetine. Ropivacaine is a cytochrome P450 3A4 and cytochrome 1A2 substrate. Fluoxetine is an inhibitor of both enzymes. Coadministration may result in ropivacaine toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::880d7b71dae4a6c2099adba6916ec536 https://doi.org/10.1007/978-1-4614-7495-1_41 Zobrazit plný text záznamu