Preparation and properties of thermo- and pH-responsive polypeptide bearing OEG and aldehyde pendants
| Autor: | Zuowen Shi, Fei Xu, Haoyu Tang, Ying Ling, Congping Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Cloud point Polymers and Plastics Imine Ether 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Grafting 01 natural sciences Aldehyde Lower critical solution temperature 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry Polymer chemistry Materials Chemistry Physical and Theoretical Chemistry 0210 nano-technology Ethylene glycol Triethylene glycol |
| Zdroj: | Colloid and Polymer Science. 298:1293-1302 |
| ISSN: | 1435-1536 0303-402X |
| DOI: | 10.1007/s00396-020-04712-6 |
| Popis: | OEGylated polypeptide bearing triethylene glycol monomethylether (OEG3) and poly(ethylene glycol) methyl ether 350 (OEG7) were first prepared by copper-mediated 1,3-dipolar cycloaddition. 1H NMR, FTIR, and GPC results indicated the successful conjugation of oligo(ethylene glycol) (OEG) pendants with high grafting efficiency (≥ 98%). Variable temperature UV–vis spectroscopy revealed a reversible lower critical solution temperature (LCST)-type phase transition of the resulting polypeptides. The LCST-type cloud point temperature (Tcp) in the range of 20–60 °C can be readily tuned by changing the OEG3 and OEG7 composition. Thermo- and pH-responsive polypeptide was prepared by first conjugating of OEG and 6-aldehyde hexyl pendants, then crosslinking in the presence of 1,6-hexanediamine, yielding OEGylated polypeptide bearing pH-labile imine bonds. The resulting polypeptide showed pH-responsive property and less pronounced thermoresponsive property at high pH values (i.e., ≥ 6.15) and noticeable thermo- and pH- dual responsive properties at low pH values (i.e., ≤ 5.80). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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