Concentrations of free thyroxin and albumin in serum in severe nonthyroidal illness: assay artefacts and physiological influences
| Autor: | C P Sheehan, N D Christofides, D. Browning, R. Mardell, J. E. Fry, J. E. M. Midgley |
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| Rok vydání: | 1990 |
| Předmět: |
Albumin concentrations
medicine.medical_specialty Chemistry Biochemistry (medical) Clinical Biochemistry Albumin Radioimmunoassay Endocrinology Free thyroxin Internal medicine Nonthyroidal illness medicine Euthyroid Quantitative analysis (chemistry) hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Clinical Chemistry. 36:765-771 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/36.5.765 |
| Popis: | Free thyroxin (FT4) estimates by two immunoassays were compared with the concentrations of albumin in serum of apparently euthyroid subjects who either were (n = 99) or were not (n = 327) suffering from severe nonthyroidal illness (sNTI). In neither group was FT4 significantly correlated with albumin (P greater than 0.05), according to a "labeled antibody" radioassay (Amerlex-MAB). On amalgamating both groups, correlation with albumin was positive and significant (P less than 0.001). In the group with sNTI, both FT4 and albumin concentrations were decreased (mean FT4 to 77% and mean albumin to 61% of the respective reference means). For an analog radioimmunoassay (Amerlex-M), FT4 in all groups was significantly (P less than 0.001) correlated with albumin. Correlation coefficients were greater than with Amerlex-MAB for both sNTI and euthyroid groups, as well as for the joint panel. Mean FT4 in sNTI was only 44% of the reference mean. Lower radio-tracer "analog" values in sNTI are exaggerated by additional technical artefacts resulting from tracer binding to albumin. |
| Databáze: | OpenAIRE |
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