Kinetics and mechanisms of the autoxidation of ketorolac tromethamine in aqueous solution
Autor: | Chiang Hi-Shi, Allyn Becker, Gu Leo |
---|---|
Rok vydání: | 1988 |
Předmět: | |
Zdroj: | International Journal of Pharmaceutics. 41:95-104 |
ISSN: | 0378-5173 |
DOI: | 10.1016/0378-5173(88)90141-x |
Popis: | The thermal reactivity of ketorolac tromethamine ( 1 ) in aqueous buffer solutions was studied at 60 °–100 ° C from pH 1.1 to 12.4. Four products ( 2–5 ) were formed and their distribution was pH dependent. The apparent degradation was both acid — and base-catalyzed and the rate depended on the oxygen concentration in a linear fashion at pH > 4.8. At low pH (2.15), however, no significant difference in rate was observed when solutions were saturated with either air or oxygen. Mechanisms involving either base-catalyzed deprotonation or uncatalyzed hydrogen abstraction at the tertiary carbon (α to the carboxylic group of ketorolac) followed by reaction with O 2 are proposed to account for the observed kinetics and product distribution at pH > 4.8. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...