| Autor: |
Chiang Hi-Shi, Allyn Becker, Gu Leo |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 41:95-104 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(88)90141-x |
| Popis: |
The thermal reactivity of ketorolac tromethamine ( 1 ) in aqueous buffer solutions was studied at 60 °–100 ° C from pH 1.1 to 12.4. Four products ( 2–5 ) were formed and their distribution was pH dependent. The apparent degradation was both acid — and base-catalyzed and the rate depended on the oxygen concentration in a linear fashion at pH > 4.8. At low pH (2.15), however, no significant difference in rate was observed when solutions were saturated with either air or oxygen. Mechanisms involving either base-catalyzed deprotonation or uncatalyzed hydrogen abstraction at the tertiary carbon (α to the carboxylic group of ketorolac) followed by reaction with O 2 are proposed to account for the observed kinetics and product distribution at pH > 4.8. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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