The α2-isoform of the Na+/K+-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction
| Autor: | Sandra Bandleon, Paula Anahi Arias-Loza, Antonella Cellini, Dorina Höfler, Christoph Maack, Wolfgang R. Bauer, Petra Eder-Negrin, Tanja Langsenlehner, Michael Kohlhaas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetically modified mouse
Gene isoform medicine.medical_specialty Physiology Chemistry Diastole chemistry.chemical_element Calcium medicine.disease Endocrinology Desensitization (telecommunications) Physiology (medical) Internal medicine medicine Myocardial infarction Na+/K+-ATPase Cardiology and Cardiovascular Medicine Pathological |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 321:H650-H662 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00808.2020 |
| Popis: | Reduced systolic and diastolic calcium levels in cardiomyocytes from NKA-α2 transgenic mice minimize the desensitization of the β-adrenergic signaling system. These effects result in an improved β-adrenergic reserve and prevent functional deterioration and cardiac remodeling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|