ChemInform Abstract: Novel Antitumor 2-Cyanoaziridine-1-carboxamides

Autor: Bhashyam S. Iyengar, Robert T. Dorr, David S. Alberts, William A. Remers, Sydney E. Salmon, Evan M. Hersh
Rok vydání: 2010
Předmět:
Zdroj: ChemInform. 30
ISSN: 1522-2667
0931-7597
DOI: 10.1002/chin.199923126
Popis: A set of 20 2-cyanoaziridine-1-carboxamides was synthesized from 2-cyanoaziridine and appropriate isocyanates. These compounds were active against a variety of solid and hematological tumor cells in culture, including strains resistant to doxorubicin and mitoxantrone. Their potencies in these assays correlated with the lipophilicity of substituents. The N-phenyl derivative was more potent and equally effective to imexon, a cyclized 2-cyanoaziridine-1-carboxamide of clinical interest, against cloned fresh human tumors.
Databáze: OpenAIRE