ChemInform Abstract: Novel Antitumor 2-Cyanoaziridine-1-carboxamides
Autor: | Bhashyam S. Iyengar, Robert T. Dorr, David S. Alberts, William A. Remers, Sydney E. Salmon, Evan M. Hersh |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 30 |
ISSN: | 1522-2667 0931-7597 |
DOI: | 10.1002/chin.199923126 |
Popis: | A set of 20 2-cyanoaziridine-1-carboxamides was synthesized from 2-cyanoaziridine and appropriate isocyanates. These compounds were active against a variety of solid and hematological tumor cells in culture, including strains resistant to doxorubicin and mitoxantrone. Their potencies in these assays correlated with the lipophilicity of substituents. The N-phenyl derivative was more potent and equally effective to imexon, a cyclized 2-cyanoaziridine-1-carboxamide of clinical interest, against cloned fresh human tumors. |
Databáze: | OpenAIRE |
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