Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs
| Autor: | Sabrina Lyngbye Wendt, Carsten Boye Knudsen, John Bagterp Jørgensen, Henrik Madsen, Ahmad Haidar |
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| Zdroj: | Technical University of Denmark Orbit Wendt, S L, Boye Knudsen, C, Jørgensen, J B, Madsen, H & Haidar, A 2016, ' Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs ' 9th International Conference on Advanced Technologies and Treatments for Diabetes (ATTD 2016), Milan, Italy, 03/02/2016-06/02/2016, . |
| Popis: | Zealand Pharma has invented a glucagon analogue, ZP-GA-1, with increased stability in liquid formulation for treatment of hypoglycemia. A pharmacodynamic (PD) model is needed to compare ZP-GA-1 with marketed glucagon. We aim to develop a model of the complex glucose-insulin-glucagon dynamics based on physiology and data. |
| Databáze: | OpenAIRE |
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