Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs

Autor:	Sabrina Lyngbye Wendt, Carsten Boye Knudsen, John Bagterp Jørgensen, Henrik Madsen, Ahmad Haidar
Předmět:	endocrine system digestive oral and skin physiology hormones hormone substitutes and hormone antagonists
Zdroj:	Technical University of Denmark Orbit Wendt, S L, Boye Knudsen, C, Jørgensen, J B, Madsen, H & Haidar, A 2016, ' Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs ' 9th International Conference on Advanced Technol​ogies and Treatments for Diabetes (ATTD 2016), Milan, Italy, 03/02/2016-06/02/2016, .
Popis:	Zealand Pharma has invented a glucagon analogue, ZP-GA-1, with increased stability in liquid formulation for treatment of hypoglycemia. A pharmacodynamic (PD) model is needed to compare ZP-GA-1 with marketed glucagon. We aim to develop a model of the complex glucose-insulin-glucagon dynamics based on physiology and data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::015258276fbc14d06d53bf796289d70d https://orbit.dtu.dk/en/publications/53d1edd3-8bc6-4d8d-af0a-3fb68eed5658 Zobrazit plný text záznamu