| Autor: |
Waku, Tomonori, Kitagawa, Yuichi, Kawabata, Kazufumi, Nishigaki, Saki, Kunugi, Shigeru, Tanaka, Naoki |
| Zdroj: |
Chemistry Letters; November 2013, Vol. 42 Issue: 11 p1441-1443, 3p |
| Abstrakt: |
Highly antigen-loaded nanofibers were successfully prepared by the self-assembly of ß-sheet forming peptides conjugated with antigenic peptides and cell penetrating peptides (CPP). The nanofibers with lengths of 240 ± 100 nm were taken up more efficiently by murine macrophage-like cells than monomeric CPP-modified antigenic peptides. This self-assembly approach may provide a facile method for creating nanoparticle-based vaccines without complicated multistep procedures. |
| Databáze: |
Supplemental Index |
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