Systematic Error Associated with Apparatus 2 of the USP Dissolution Test V: Interaction of Two Tableted Prednisone Formulations with Glass and Plastic Vessels

Autor: Coxx, Don C., Furman, William B.
Zdroj: Journal of Pharmaceutical Sciences; August 1984, Vol. 73 Issue: 8 p1125-1127, 3p
Abstrakt: Recently marketed glass vessels that are uniform and pass USP specifications were compared with uniform plastic vessels that also pass USP specifications. Two lots of prednisone tablets, Tablet 1 and Tablet 2, were tested in both types of vessels. Tablet 1 gave higher results (+12.7% of label claim) in glass vessels at 50rpm but gave equivalent results in either vessel at 75rpm. Tablet 2 gave equivalent results in either vessel at 50rpm but gave higher results (+22% of label claim) in glass vessels at 75rpm. The type of vessel used to obtain dissolution results for tablets should be specified.
Databáze: Supplemental Index