The Expression of Human Leukocyte Antigen‐G on Trophoblasts Abolishes the Growth‐Suppressing Effect of Interleukin‐2 towards Them

Autor: Hamai, Yoko, Fujii, Tomoyuki, Yamashita, Takahiro, Miki, Akinori, Hyodo, Hironobu, Kozuma, Shiro, Geraghty, Daniel E., Taketani, Yuji
Zdroj: American Journal of Reproductive Immunology; February 1999, Vol. 41 Issue: 2 p153-158, 6p
Abstrakt: PROBLEM: We have shown the attenuated human leukocyte antigen (HLA)‐G expression on trophoblasts and an aberrant expression of interleukin (IL)‐2, a cytotoxic cytokine, in decidual tissue in preeclampsia, where deteriorated trophoblastic invasion into decidual layers may constitute a crucial pathogenesis. We hypothesized that the absence of HLA‐G might make trophoblasts susceptible to compromise by IL‐2.
Databáze: Supplemental Index