MEKK3 Expression Correlates With Nuclear Factor κ B Activity and With Expression of Antiapoptotic Genes in Serous Ovarian Carcinoma.

Autor: Samanta, Ajoy K., Huang, Helen J., Le, Xiao-Feng, Mao, Weiqun, Lu, Karen H., Bast Jr., Robert C., Liao, Warren S.-L.
Předmět:
Zdroj: Cancer (0008543X); 9/1/2009, Vol. 115 Issue 17, p3897-3908, 12p, 8 Graphs
Abstrakt: The article presents a study on the MEKK3 expression with nuclear factor κ B activity and the role of antiapoptic genes in ovarian cancer. A background on ovarian cancer and the effect of nuclear factor κ B in the development of cancer is given. The study uses Western blotting and real-time polymerase chain reaction. Results show that ovarian cancer with high MEKK3 also showed high nuclear factor κ B activity. It concludes that MEKK3 plays an important role in tumors.
Databáze: Complementary Index