Estrogen Receptors: How Do They Signal What Are Their Targets.

Autor: Heldring, Nina, Pike, Ashley, Anderson, Sandra, Matthews, Jason, Goujun Cheng, Hartman, Johan, Tujague, Michel, Ström, Anders, Treuter, Eckardt, Warner, Margaret, Åke^Gustafsson, Jan
Předmět:
Zdroj: Physiological Reviews; Jul2007, Vol. 87 Issue 3, p905-931, 27p, 7 Diagrams, 4 Charts
Abstrakt: The article focuses on the new insights into estrogen receptor modulation by synthetic anti-estrogens and coregulatory proteins and discuss the molecular concept of anti-estrogen signaling. It discusses the roles of ERα and ERβ in mediating growth and morphogenesis. It is suggested that an understanding of the multifaceted estrogen receptor signaling is important from a preclinical and clinical perspective.
Databáze: Complementary Index