University of Otago Researchers Describe New Findings in Mycobacterium tuberculosis (Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis).

Předmět:	MYCOBACTERIUM tuberculosis MYCOBACTERIAL diseases GRAM-positive bacteria NIACIN ACTINOMYCETALES
Zdroj:	TB & Outbreaks Week; 12/6/2024, p4332-4332, 1p
Abstrakt:	University of Otago researchers conducted a study on Mycobacterium tuberculosis, focusing on drug-resistant strains and the vulnerabilities they present. The research identified potential pathway targets to combat isoniazid resistance by analyzing an isoniazid-resistant katG mutant strain of M. tuberculosis. The study highlighted how changes in the physiology of drug-resistant strains can generate druggable vulnerabilities that may improve clinical outcomes. The findings were published in Nature Communications and funded by the Health Research Council of New Zealand. [Extracted from the article]
Databáze:	Complementary Index
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