Fudan University Researchers Reveal New Findings on Blood Transfusion (Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium...).

Předmět:	CELL-matrix adhesions FOCAL adhesions FOCAL adhesion kinase CELL anatomy TISSUE adhesions CYTOSKELETAL proteins
Zdroj:	Blood Weekly; 8/29/2024, p196-196, 1p
Abstrakt:	New research from Fudan University explores the concept of acidic preconditioning (AP) and its potential protective effects on kidney injury. The study found that short-term, repetitive acidic stimulation can enhance a cell's ability to withstand subsequent adverse stress. In both in vitro and in vivo models, AP was shown to effectively mitigate hypoxia/reoxygenation (H/R) injury in kidney cells. The study also identified the involvement of the FAK/NOX4/NHE1 signaling pathway in maintaining intracellular pH homeostasis and promoting cytoskeletal remodeling. These findings provide evidence for the potential therapeutic application of AP in kidney injury. [Extracted from the article]
Databáze:	Complementary Index
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