| Autor: |
Gao, Yuhan, Yang, Ruhui, Shou, Zeyu, Zan, Xingjie, Tang, Sicheng |
| Předmět: |
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| Zdroj: |
Chemical Communications; 7/4/2024, Vol. 60 Issue 52, p6683-6686, 4p |
| Abstrakt: |
This study introduces boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery. Tuning the hydrophobic/hydrophilic balance optimized the size, curcumin encapsulation, ROS-triggered release, cellular uptake, and intracellular ROS scavenging. The lead P1b formulation self-assembled into stable 10 nm micelles enabling rapid ROS-triggered curcumin release and preferential cellular internalization. P1b eliminated over 90% of pathogenic intracellular ROS within 10 minutes, demonstrating a rapid antioxidant therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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