Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery.

Autor: Gao, Yuhan, Yang, Ruhui, Shou, Zeyu, Zan, Xingjie, Tang, Sicheng
Předmět:
Zdroj: Chemical Communications; 7/4/2024, Vol. 60 Issue 52, p6683-6686, 4p
Abstrakt: This study introduces boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery. Tuning the hydrophobic/hydrophilic balance optimized the size, curcumin encapsulation, ROS-triggered release, cellular uptake, and intracellular ROS scavenging. The lead P1b formulation self-assembled into stable 10 nm micelles enabling rapid ROS-triggered curcumin release and preferential cellular internalization. P1b eliminated over 90% of pathogenic intracellular ROS within 10 minutes, demonstrating a rapid antioxidant therapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index