SYNTHESIS OF NOVEL 2-(4-ALLYLPIPERAZIN-1-YL)-1-(1- ARYL-1H-TETRAZOL-5-YL)ETHANONE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS.

Autor: Zaidi, Zoya, Amudharaj, M., Anusuya, V., Sujatha, G., Balaji, G. L.
Předmět:
Zdroj: Rasayan Journal of Chemistry; Jul-Sep2021, Vol. 14 Issue 3, p2077-2084, 8p
Abstrakt: A series of novel 2-(4-allylpiperazin-1-yl)-1-(1-aryl-1H-tetrazol-5-yl) etalons were synthesized with excellent yields by the reaction of 1-(1-aryl-1H-tetrazol-5-yl)-2-(piperazin-1-yl) ethanones with allyl bromide and one equivalent of triethylamine in acetonitrile under nitrogen atmosphere. Spectral data (FT-IR, 1H NMR, 13C NMR, and HSQC) was used to characterize all produced substances and screened against antimicrobial activities. A few of the compounds were shown to be as potent as or more effective than conventional medicines. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index